What is the effect of synthetic phospholipid distearyl phosphatidylglycerol DSPG?

Synthetic phospholipid distearyl phosphatidylglycerol. Do you know? Distearyl phosphatidylglycerol, also known as DSPG, is chemically known as 1, 2-distearyl -Sn-glycerol -3-phosphate glycerol, sodium of which CAS number is 124011-52-5.

Now, after watching this video, what does dicstearyl phosphatidylglycerol do?

DSPG-NA is suitable for the preparation of liposomes, and the most typical case is Ambisome, a liposome of amphotericin B. Ambisome is the world's first GE liposome product developed by Nexstar, which was later acquired by Gilead. It was listed in Europe in 1990 and in the United States in 1997. The product is a freeze-dried preparation, used for the treatment of severe deep true Jun RAN, such as kala-azar, yeast disease, coccoidiomycosis, etc. It can also be used for zhi treatment of RAN induced by Aspergillus and Jun beads.
Ambisome uses negatively charged phospholipid DSPG to bind to positively charged trehalosamine in the structure of amphotericin B to stably encapsulate the drug, so API amphotericin B exists on the phospholipid bilayer. The cholesterol in Chu formula acts hydrophobically with the drug molecules. Specifically, CHU formula is HSPC:CHOL:DSPG: AMB = 2:1:0.8:0.4 (molar ratio), and the particle size of the product is about 100nm. As the first liposome preparation listed in the world, amphotericin B liposome can be said to be a milestone in the field of preparations. Although it is listed early, but in the foreign market has been very good, can fully stand the long-term test of clinical and market.

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