What is dulaglutide? What are the effects of dulaglutide? Where can I buy dulaglutide?

What is dulaglutide? The role of dulaglutide? Where to buy dulaglutide?

Trulicity is a human glucagon like peptide-1 (GLP-1) receptor inhibitor. Its main component is dulaglutide. It is a fusion protein. Its single molecular structure is composed of two identical polypeptide chains linked by disulfide bond. Each polypeptide chain is encoded by N-tail GLP-1 analog and decorated human IgG4 heavy chain FC segment, which is covalently linked according to a small segment of linked peptide Then, according to the production and manufacture of small hamster uterus and ovary somatic cells in China. The GLP-1 analogue coding sequence of dulaglutide is 90% identical with that of pure natural human GLP-1, in which part of GLP-1, which is responsible for the interaction with dipeptidyl peptidase Ⅳ, introduces structural decoration. In addition, part of potential T-cell epitopes and IgG4, which is responsible for the fusion with high affinity Fc receptor and the FC generated by hapten, also carries out decoration, with the total relative molecular weight of about 63kda.

Dulaglutide (trade name: trulicity), a high-efficiency GLP-1 analogue developed by Lilly products, was approved for treatment of type 2 diabetes in the UK in September 2014. Structurally, dulaglutide replaced ala with Gly at the eight positions of GLP-1 (7-37), Gly at the 22 positions of GLP-1 (7-37) chain and Arg with Gly at the 36 positions of GLP-1 (7-37) chain, with a mean half-life of 90 H. In March 2014, the results of clinical medicine showed that dulaglutide was not inferior to lilalutide in efficacy, and it was the first biomacromolecule GLP-1 analogue not inferior to lilalutide in efficacy. However, the frequency of dulaglutide once a week can significantly improve patients' compliance, which is a new product with great development potential and competition with Lila chemical book.

GLP analogues contain GLP-1 analogues and GLP-2 analogues. GLP-1 analogues are essential for type 2 diabetes. Drugs on sale include exenatide, lilalutide, lisnertide, dulaglutide and abirotide. GLP-2 analogues are used for short bowel syndrome, and only tiludulin is available at this stage. GLP-1 analogues are a popular active peptide industry for scientific research at this stage. The length of peptide chain is based on 31-44 carbohydrates, and there is no disulfide bond in the structure. At present, the best-selling types of GLP-1 analogues are mainly lilalutide and exenatide. The total sales volume of the two analogues has already exceeded US $3 billion. Some investment analysts predict that the sales market of GLP-1 analogues may increase by US $6 billion in five years.

nature

Where to buy dulaglutide?

Hangzhou gutuo is a biotechnology enterprise engaged in pharmaceutical intermediates, customized active peptides, skin care products active peptides and other commodities. It can produce pharmaceutical intermediates and active peptide chemical intermediates in large quantities. Dulaglutide original solution supplied by the enterprise is a sterile test, clear and colorless solution.

If there is any reprint of the original article, please indicate the source: "this article was first published in Guto peptide synthesis Biotechnology Co., Ltd（ www.gotopbio.com ）”