The properties of hydroxypropyl betadex

Hydroxypropyl betadex (HP-β-CD) is a hydrophilic derivative of beta-cyclodextrin (HP-β-CD) condensed with 1,2 epoxy-propane. The hydroxyl groups on R1, R2 and R3 of beta-cyclodextrin are randomly replaced by hydroxypropyl groups to generate 2-HP-β-CD, 2, 3-HP-β-CD, 2, 6-HP-β-CD and 2, 3. 6-HP-β-CD and other homologues. By hydroxypropylation of β-CD, the intramolecular hydrogen bonds were broken, and the solubility of β-CD was significantly improved.

Hydroxypropyl betadex has low nephrotoxicity and high safety, but there is a hemolytic reaction at high concentration. As pharmaceutical excipients, it is mainly used as solvent-increasing, stabilizer and permeability enhancer. The active development and utilization of this multifunctional excipient is beneficial to improve the quality and bioavailability of the product, so as to enhance the technical level of the preparation.

Shandong Binzhou Zhiyuan Biotechnology Co., Ltd. has been producing hydroxypropyl betadex for more than ten years, and the product has obtained DMF record number: 030168.You can call us 0086-543-2616568.