The Broad Development Prospect Of Betadex-Sulfobutyl-Ether-Sodium

Betadex-sulfobutyl-ether-sodium(SBE-β-CD) is a polyanionic β-cyclodextrin derivative with a round-shaped shape, hydrophobic inside the round table, externally connected with a hydrophilic sulfobutyl ether substituent, and a round table. The alkyl ether portion of the inner and side chains can better accommodate hydrophobic drug molecules, and has the advantages of improved drug solubility, improved drug stability, and the like. Since the market for voriconazole for injection, the FDA has approved 9 An injection product using betadex-sulfobutyl-ether-sodium solubilized promotes the study of the properties, analytical methods, safety and application of sodium sulfobutyl beta-cyclodextrin. Betadex-sulfobutyl-ether-sodium has a good solubilizing effect on poorly soluble drugs, and the stability of the pharmaceutical preparations is obviously improved, and the solubility is obviously increased. And its nephrotoxicity is lower than the general beta-cyclodextrin, and has broad development prospects.