The application of hydroxypropyl beta cyclodextrin in gambogic acid

Gambogic acid is an active monomer isolated from traditional Chinese medicine in gamboge. Confirmed by research in recent years, gambogic acid has significant antitumor activity, within the scope of the effective dose to the tumor cells to select high inhibitory, and hemopoietic system and immune function of normal animals less obvious influences, and side effects of small, these advantages are currently not possessed by other tumor chemotherapy drugs. At present a large number of studies have shown that gambogic acid is a kind of multiple targets of anti-tumor drugs, can inhibit cell proliferation, cell cycle arrest, promote cell apoptosis and inhibit tumor angiogenesis, new block and metastasis of the tumor and other ways to achieve the purpose of antitumor.

But the poor water solubility of gambogic acid, Zhiyuan bio R&D department developed gambogic acid hydroxypropyl beta cyclodextrin, greatly improving the solubility and stability of gambogic acid, solves the problem of gambogic acid in clinical application.