Solubilization of loratadine by Hydroxypropyl betadex

Loratadine belongs to the second generation of H2 receptor antagonist, which is a powerful and long-acting tricyclic antihistamine. It is mainly used in the treatment of allergic rhinitis, seasonal rhinitis, skin allergy, urticaria and allergic asthma. Loratadine is a fat soluble drug, which is difficult to dissolve in water, resulting in slow absorption and low bioavailability.

In recent years, cyclodextrin has become the most widely used insoluble drug inclusion materials, especially the hydrophilic hydroxypropyl betadex can improve the solubility, dissolution rate and bioavailability of drugs. The results showed that the solubility of loratadine was the highest when the pH of hydroxypropyl betadex was 3.5. However, when the pH was 5.5 and 6.5, the drug was mainly incorporated into hydroxypropyl betadex in molecular form, and the drug was more stable. Therefore, although the oil-water distribution coefficient of the drug was greater than that of pH 4.5, the concentration of the drug was still greater than that of pH 4.5.

Shandong Binzhou Zhiyuan Biotechnology Co., Ltd. is an enterprise specializing in the production of cyclodextrin. If you have any questions and want to solve some problems related to cyclodextrin, please call 0086 543-2616568.