Preparation of cordycepin hydroxypropyl - cyclodextrin inclusion complex

Preparation of cordycepin hydroxypropyl - cyclodextrin inclusion complex

Cordycepin (COR), also known as Cordyceps sinensis, active ingredient of Cordyceps sinensis in traditional Chinese medicine. The study showed that cordycepin has antitumor, antifungal, inhibit the growth of microorganisms, anti-inflammatory, hypoglycemic, anti atherosclerosis and other medicinal effects. Especially for treatment of leukemia, has good clinical application prospect the wild Cordyceps sinensis. But limited resources, and the content of medicinal active ingredient of cordycepin is low, and the bioavailability is low water solubility, in vivo stability, easy degradation and loss of activity, leading to its application in pharmaceutics is limited. Therefore, the research of drug excipients effectively to enhance the stability of cordycepin the significance of water solubility and bioavailability.Cyclodextrin and its derivatives (CD) is a kind of fat soluble drug carrier, has been the focus of research. The derivatives of hydroxypropyl beta cyclodextrin (HP- beta -CD) in medicine, food, cosmetics and other fields are widely used. Mainly because of the cavity size of HP- beta -CD the good water solubility, in the body of the side effects of small, cheap and easily obtained raw materials, and to improve drug solubility and bioavailability have significant effect. The study shows that the formation of COR and HP- beta -CD clathrate inclusion ratio of 1: 1, HP- beta -CD can significantly increase COR water solubility and stability of.COR after the formation of inclusion complexes, its solubility increased from 4.3 mg /mL to 170.5mg /mL, increased by 39.6 times, the decomposition temperature is increased from 200 to 261 DEG C.. This indicates that as a drug carrier, HP- COR beta -CD to improve the water solubility and stability play a great for use.

Shandong Binzhou Zhiyuan Biological Technology Co. Ltd. is specializing in the production of cyclodextrin manufacturers, hydroxypropyl times of the production of betacyclodextrin has obtained approval, and has also been in the United States FDA registration. With the intention to cooperate enterprises welcome for enquiry, 0543-2616568.