New Cationic Lipid DLin-MC3-DMA

The cationic lipid DLin-MC3-DMA, a key excipient for the siRNA liposome product Onpattro. It's officially live at AVT!
2018 World's first siRNA liposome product for the treatment of familial amyloid polyneuropathy Onpattro has been successfully launched in the US, opening the door to silencing cellular genetic drugs.

▲Onpattro

The cationic lipid material DLin-MC3-DMA used in Onpattro is also attracting attention.

▲ Specific amounts of each component of Onpattro

Until then, DLin-MC3-DMA remained a blank slate in the domestic market.AVT is based on a deep commitment to phospholipid, liposomal, and With years of resources and experience in the direction of fat emulsions, a new product, DLin-MC3-DMA, was launched. A "low toxicity and high efficiency" option.
Cationic liposomes, as the name implies, are preparations of liposomes in which the particles are positively charged, so cationic lipids that provide positive charge are the preparations Key. The most common and widely used cationic lipids on the market today are DOTAP, DOTMA, DC-CHOL, etc., but  they all have high cytotoxicity in applications, so it is often difficult to balance between drug loading and safety.
DLin-MC3-DMA, as the representative of new cationic lipid, ionizable cationic lipid, has low toxicity and high efficiency. "The advantage of the chemical name 4-(N,N-dimethylamino)butyric acid (6Z,9Z,28Z,31Z)- Heptadecan-6,9,28,31-tetrahydron-19-yl lipid, molecular formula C43H79NO2, is a colorless to Pale yellow oily liquid, pKa=6.44.

▲DLin-MC3-DMA structural formula

DLin-MC3-DMA has unique pH-dependent charge variable properties: positive under acidic conditions, while physiological pH conditions are electrically neutral. As a result, nucleic acids are encapsulated in acidic conditions and the liposomes formed have a very low positive charge density in the blood, i.e. very low cellular toxicity. And DLin-MC3-DMA cationic liposomes can increase the lysosomal escape of particles in the body due to their positive electrical properties, and enhance the transfection efficiency without being susceptible to phagocytosis by macrophages. Taking advantage of these properties, the cationic liposomes prepared from DLin-MC3-DMA have " Low toxicity and high efficiency".
Some of you may be wondering what is so special about sucrose products.
The boys know that sucrose is a non-reducing disaccharide, consisting of one molecule of glucose hemiacetal hydroxyl group and one molecule of fructose hemiacetal hydroxyl group. AVT's sucrose products are high purity, low endotoxin injectable grade pharmaceutical sucrose, which is often used in pharmacology as the basis for The lyophilization protectant is used in nano-formulations and protein biological products. It acts as a low-temperature protectant in the freeze-drying process and as a dehydration protectant in the drying and dehydration process, and it can also adjust the osmotic pressure. , which is recognized as one of the most widely used and effective freeze-drying protectants.
In addition to DLin-MC3-DMA, AVT has several cationic lipids that are essential for liposome preparation.The development of Chinese RNA drugs will be greatly facilitated by DC-CHO，DOTAP, DMG-PEG2000 and DOTMA !
For more information about cationic lipid materials, especially DLin-MC3-DMA, please contact us at 400-6262-623.