Nature: Recent discovery of human recombinant collagen polypeptide as a versatile biomaterial for bo

Recently, Hideo Fushimi, a Japanese Fuji company, and others published Recombint collagen polypetide asatilebone graftbiomaterial in the Journal of Communications Materials.

ABSTRACT: Self-transplantation and allotransplantation are currently regarded as the gold standard for transplantation.However, synthetic biomaterials will play an increasingly important role in order to meet the growing demands of a rapidly aging society.Here, biodegradable scaffold materials are reported.The material is composed of a recombinant polypeptide of human collagen type I alpha 1 chain (RCPhC1) and is a source of hydrogel-based graft materials.Demonstrates flexibility in designing ideal bone graft properties.Important internal isotropic pore structures are generated by a designed thin-layer Freeze-casting technique.By adjusting the amino acid composition of RCPhC1, the optimal biodecomposition rate was controlled by dehydrogenation cross-linking.After all, RCPhC1 bone grafts produced through highly scalable simplified production schemes are fully absorbed in preclinical animal models while guiding robust regeneration of mature bone tissue.

Human recombinant collagen polypeptide.

Engineering factors affecting the dehydrogenation crosslinking of RCPhC1 to control the biodegradation rate and mechanical strength.

Pre-clinical efficacy testing of RCPhC1 material optimized for bone grafting in dental and dog models was performed.

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