Methyloprim Betadex sulfobutyl ether sodium envelope

 Methylrim is a spectral antimicrobial, often used in combination with sulfamines, also known as sulfamide stimulants. However, its taste is bitter, extremely slightly soluble in water, and it is generally difficult to see methyloprim water-soluble dosage form and powder needle dosage form for clinical use. Use alone can be used for respiratory infections, urinary tract infections, intestinal infections and other diseases. However, the strong hydrophobic use had low dissolution rate and small bioutilization, which greatly limited the use and efficacy of the drug.

Betadex sulfobutyl ether sodium as a pharmaceutical auxiliary has been widely used to increase the water soluble, stability, dissolution rate and bioavailability of insoluble drugs, with its special "external hydrophilic, inner hydrophobic" molecular structure can form compounds with the hydrophobic group of guest molecules matching some polarity, size, shape and properties.

Although methylrim improves its water-soluble properties by forming lactic salts, the API and the API salts it formed may differ more or less in the pharmacology, efficacy, absorption, and bioavailability of the drug. At the same time, the nature of the drug will also change.

Betadex sulfobutyl ether sodium and methyloprim combine to form a package, which can improve the hydrosolvent of methyloprim and realize the expansion goal of the preparation of the corresponding hydrosolution dosage form and powder needle dosage form of methyloprim.