Manufacturers of hydroxypropyl-beta-cyclodextrin

In recent years, the biological activities of Capsicum alkaloids have attracted much attention, including anti-tumor, anti-inflammatory, pain relief, weight loss, prevention of cardiovascular disease and protection of gastrointestinal system. Bioavailability of active substances is mainly determined by bioavailability, absorption rate and conversion rate. Bioaccessibility depends on the release of active substances from food matrix and their dissolution in gastric juice. Although capsicum alkaloids have high bioactivity, their bioaccessibility is low due to poor solubility.

Hydroxypropyl-beta-cyclodextrin (HP-β- CD) is often used as solubilizer and excipient of drugs because of its low relative surface activity and hemolytic activity, high solubility and no irritation to muscle. 20% (w / V) HP-β- CD was the most suitable concentration, and its cumulative penetration and time were 1.31 and 1.38 times of that of free cap, respectively.The solubilization of capsaicin-HP-β-CD was significantly improved in vivo, and the bioavailability of capsaicin-HP-β-CD increased to 139.38%. Using HP-β- CD the results show that the method of cd-mb embedding can increase the absorption, transformation and sustained-release of Capsicum alkaloids, improve the efficacy, maintain the efficacy time, and solve the problem of low bioavailability of some capsicum alkaloids.

Shandong Binzhou Zhiyuan Biotechnology Co., Ltd. has been producing cyclodextrin for more than ten years. Welcome to contact us at 0086 543-2616568.