Intelligent source biological cyclodextrin - embedded carrier

Cyclodextrins are characterized by the ability to insert guest - active molecules into the inner pores.The inclusion technique of cyclodextrin refers to the technique of forming a inclusion compound by inserting a molecule into a hole in the molecular structure of cyclodextrin (or a derivative of cyclodextrin).The application of this technology in pharmacy is remarkable and promising.Cyclodextrin inclusion is a new type of drug carrier developed in recent years. It is a kind of non-bonding complex formed by completely or partially encapsulating the drug molecules in the cyclodextrin macromolecular hollow cylindrical special structure.Its dosage form is similar to microcapsules, but cyclodextrin has a single-molecule level of drug inclusion, so it is also called molecular capsule. This technology can produce special effects that microcapsules and nanocapsules do not have.For example, total trans-retinoic acid is a fat-soluble drug, less stable, sensitive to light, temperature and air, and easily oxidized.If the product is prepared by cyclodextrin inclusion technology, the solubility, stability, bioavailability and irritation of the drug as the guest molecule will be significantly increased after inclusion.Such combination of the microcapsule of compound molecular level makes the active ingredients of medicines and cosmetics have the function of the slow release and targeted, there are many manufacturers use the cyclodextrin inclusion technology reduce inclusion object (active component) of blood vessels, skin, gastrointestinal and other irritating, reduce bad taste, enhance the efficacy of (active component), reduce the side effects of drugs on the human body, enhance the solubility of the products.