Inclusion technology of volatile oils in antihypertensive nasal spray

Chinese medicine with antihypertensive effect is made into nasal spray, which is used in the treatment of hypertension. The main components of this preparation are Angelica sinensis, Magnolia, mint, Prunella vulgaris and so on. Flos magnolia and mint contain volatile oil, which has a certain effect on the efficacy of the drug. Because of its poor stability, volatile, volatile and poor solubility in water, it affects its bioavailability.The preparation of volatile oil into inclusion compounds can not only improve stability, reduce volatilization, but also increase water solubility, improve bioavailability, and reduce the irritation and side effects of drugs.
Hydroxypropyl-β-cyclodextrin can successfully encapsulate the mixed volatile oil, after inclusion, it can obviously increase the light and thermal stability of the mixed volatile oil, and the inclusion does not affect the properties of its chemical composition. The inclusion of volatile oil can obviously promote the absorption of the preparation.
The introduction of hydroxypropyl group breaks the intramolecular cyclic hydrogen bond of Beta cyclodextrin and overcomes the main disadvantage of poor water solubility of Beta cyclodextrin while maintaining the empty cavity of cyclodextrin.

Medicinal grade Hydroxypropyl-β-cyclodextrin is an ideal injection solvent and drug excipient. Its main functions in medicine are as follows:
1. Solubilization, dissolving insoluble drugs, improving the solubility of active components of oily drugs, targeting drug delivery and protecting the effectiveness of drug components.
2. Improve the bioavailability of drugs, so that the efficacy of the drug increased or reduced the amount of use.
3. Adjust or control the release rate of drugs, reduce the side effects of drugs.
4. Cover up bad smells.