Inclusion of danpiphenol cyclodextrin

Danphenol is one of the main effective components of peony skin and Xu Changqing, volatile, poor water solubility and irritant to gastrointestinal mucosa. In order to reduce its volatility, increase water solubility, improve stability and bioavailability, literature has been reported to sullate Danphenol into salt, and Danphenol β-CD was prepared by ultrasonic method, but the binding rate is not high.The coating of hydroxypropyl β-CD by saturated solution can significantly improve the binding rate, reduce the volatilization of danphenol content and increase its water-soluble effect.

To improve the binding rate and yield, it is necessary to dissolve daniphenol in a certain solvent to make a molecular state.Because danpiol is dissolved in ethanol, ether, acetone, chloroform, benzene and carbon disulfide, considering that ether is flammable and explosive, toxic solvents except ethanol and ether, in order to prevent these solvents with finished products, ethanol is used as a dispersion solvent.As the amount of ethanol increases, the wrapping rate increases, and when the amount increases to the amount of 8-fold (the ratio of ethanol to water is about 1:10).

The advantages of oral hydroxypropyl beta cyclodextrin products produced by our company are as follows:
. CDE Registration number: F20209990366
·Hydroxypropyl times cyclodextrin obtained approval for production of medicinal auxiliary materials, approval number: F2015001
· Ability to provide a complete set of information documents required by the pharmaceutical factory declaration
· Hydroxypropyl times his cyclodextrin has been filed for US FDA, DMF record number 030168
· Quality assurance: manage production in strict accordance with GMP standards
· Zhiyuan Biotechnology has a strong supply capacity, hydroxypropyl times his cyclodextrin annual output of 3,000 tons