Inclusion compound of itraconazole hydroxypropyl betacyclodextrin (hp--cd)

Itraconazole is a triazole antifungal agent with broad spectrum antifungal activity and good tolerance. Itraconazole capsules have been used in clinical practice for many years and have excellent efficacy in the treatment of superficial and subcutaneous fungal infections.But the absorption of capsule is unstable, which limits its application.Johnson & Johnson's 40% hp-ao-cd solubilized ittronazole oral solution and intravenous injection were approved by FDA in the 1990s, which is the first intravenous injection containing hp-ao-cd since hp-ao-cd was approved by FDA as the first derivative of betacyclodextrin for intravenous injection.It solves the difficulty in the treatment of severe patients who have difficulty in swallowing and patients with invasive infections who need to reach the minimum steady-state concentration as soon as possible.Shandong binzhou zhiyuan biological technology co., ltd. is a high-tech enterprise focusing on the development, production and application of cyclodextrin derivatives and cyclodextrin inclusion compounds.The company has passed the ISO9001 quality system certification, its hydroxypropyl betacyclodextrin has been registered approval, sulfobutyl betacyclodextrin sodium has been clinical approval;Hydroxypropyl betacyclodextrin and sulfobutyl betacyclodextrin sodium have been registered with FDA for the record, and obtained the DMF record number.Products have independent intellectual property rights, sold to Europe, the United States, Japan, South Korea, India, Pakistan, South America, the Middle East and other countries and regions, many times to accept customer audit and obtain great recognition and praise!The purpose of the company is "continuous progress, win your recognition and recommendation"!"Research sophisticated, long history" wisdom source biological is willing to sincerely look forward to working with you to create a better future!