Inclusion complex of curcumin and Betadex sulfobutyl ether sodium

Curcumin is a chemical component extracted from the roots and stems of some plants in Zingiberaceae and Araceae. Medical research shows that curcumin has the functions of reducing blood lipid, anti-tumor, anti-inflammatory, choleretic, antioxidant and so on. Curcumin has been found to help treat drug-resistant tuberculosis. Curcumin is orange yellow crystalline powder, slightly bitter taste, insoluble in water, but sensitive to light, heat, iron ions, poor light, heat resistance, iron ion resistance. Sulfobutyl beta cyclodextrin sodium is an anionic high water-soluble cyclodextrin derivative, which can form a non covalent complex with drug molecules, so as to improve the stability, water solubility and safety of the drug, reduce the renal toxicity, alleviate the hemolysis of the drug, control the drug release rate, cover up the bad smell, etc.

The solubility of curcumin was greatly improved by the inclusion of sulfobutyl - β - cyclodextrin sodium, and the problems of poor light resistance, heat resistance and iron ion resistance were solved, and the problem of dissolution rate in the form of tongue tablet was overcome. It has a great development prospect.