In depth understanding of active polypeptide components of the skin antimicrobial peptides anti infl

According to the Journal of clinical dermatology, acne is a chronic inflammatory skin disease that occurs in adolescence and mainly involves the facial hair follicles and sebaceous units.The incidence of acne in the Chinese population is 8.1%.However, studies have found that more than 95% will have various degrees of acne, and 3% to 7% of acne patients will leave scars that greatly affect their physical and mental health.The etiology of acne can be divided into two categories: first, P. acnes proliferation due to exuberant sebum secretion, inflammation due to abnormal keratinization of hair follicle ducts, and second, P. furiosus folliculitis.Propionibacterium acnes is a Gram-positive anaerobic Brevibacterium that parasitizes intracellularly and belongs to the normal flora of the skin, which usually resides in the hair follicles and sebaceous glands of the skin.As the development of adolescents matures, the follicular mouth appears angular plugs, and the secretory function of sebaceous glands is significantly enhanced, which is suitable for the growth and reproduction of P. acnes, and becomes one of the important etiological factors of acne.In addition, several genes of this bacterium produce some enzymes and immunogenic proteins that break down skin tissue, thus aggravating acne.In addition to the acne mentioned above, there may also be folliculitis caused by M. furiosus, and certainly there may also be folliculitis caused by other microorganisms.

                                       Acnes caused by acne causing microorganisms cross sectional diagram..jpg

Common therapeutic components and their shortcomings

Acnes is generally treated by both internal and external use.Oral intake is preferred in patients with severe acne.Ingredients are mostly tretinoins and tetracyclines that inhibit oil secretion, but have strict indications and should be used under physician guidance.Commonly used topical medications are tretinoin, azelaic acid, and salicylic acid, which can normalize follicular hyperkeratosis and prevent the formation of microanes, and antibiotics such as dexamethasone, clindamycin, and chloramphenicol can be used to reduce the number of proinflammatory microorganisms.In view of this, elimination of acne causing microorganisms is a necessary and indispensable process in the treatment of acne.Antibiotics as primary fungicides, additions are strictly prohibited in cosmetic regulations.Drugs, even when used legitimately, have varying degrees of irritation and require long-term establishment of tolerance, with doubts about potential drug resistance.

                                                         List of common acne guidelines

Important progress has been made in the development of novel anti acne peptides, and the side effects of anti acne products are eliminated

To address the widespread drawbacks of acne products, many national high-technology enterprises began to drill through the area of investigating the application of dermally active peptides for acne treatment.Among them, most attention is paid to active polypeptide complexes named antimicrobial and anti-inflammatory peptides, which were developed by Shenzhen vici pharmaceutical R & D Co., Ltd. Antimicrobial peptides, named in English as wkpepanti acnepeptide, is a novel lipid oligopeptide with anti acne effects developed based on the pathogenesis of acne.Because of its structure as a lipid modified molecular structure, high bioavailability, can be rapidly absorbed by the skin, deep into the root of vaccinia, dissolving the cell membrane of common pox causing microorganisms.Its mic value against P. acnes is only 31 ppm [2] (the antibacterial capacity of bactericides is generally the minimum inhibitory concentration (MIC).)。Anti inflammatory peptide, named in English as wkpep multi soothing peptide-1-1, is an anti-inflammatory soothing compound peptide that achieves anti-inflammatory soothing effect through two pathways:

1. Acting on opioid μ receptors, re acting on TRPV1 receptors, the human body produces a reduced number of proinflammatory mediators such as calcitonin gene-related peptide (cgpr) and substance P (SP), decreased stimulation / excitation of neurons, increased skin tolerance threshold, and diminished cutaneous discomfort to various stimuli, pain, etc.

2. When the skin is stimulated by UV light, keratinocytes in the skin epidermis are induced to produce melanocyte stimulating hormone precursor (POMC), which further produces melanocyte stimulating hormone (α - MSH), which is considered an important regulator of cutaneous immune and inflammatory responses.It is an endogenous polypeptide composed of 13 amino acids.α - MSH further acts on keratinocytes, thereby promoting the production of proinflammatory cytokines such as interleukin-1, interleukin-6, interleukin-8, and tumor necrosis factor - α.IL-8 is a chemotactic cytokine that can promote the chemotaxis of inflammatory cells and induce cell proliferation.Tumor necrosis factor - α is a potent proinflammatory cytokine that promotes increased vascular permeability and contributes to skin edema and redness.Anti inflammatory peptide is a biomimetic peptide with efficacy similar to that of α - MSH, but binds to mc1-r more easily, which can effectively reduce the production of inflammatory mediators produced by UVB induction through binding and activating the mc1-r receptor.After in vitro testing, a 1 / 30 dose of dexamethasone was required for the anti-inflammatory peptide to achieve the anti-inflammatory effect of dexamethasone by inhibiting the UVB induced release of TNF - α from keratinocytes.

                             Anti inflammatory mechanistic pathways by anti-inflammatory peptides.jpg

                                    Bacteriostatic pathways for cell membrane lysis of antimicrobial peptides

Dermally active polypeptides that witness the future of Dermatology

Skin active peptides are stable in nature and the production process is easy to control, which has become a research and development hotspot.The Chinese cosmetic polypeptide industry is currently in its infancy and growth stage, with a great potential for development.Antimicrobial peptides and anti-inflammatory peptides, because of their characteristics for acne treatment efficacy, will be widely used in the related areas of acne treatment in the future.

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GoTop peptide Biotech Co., Ltd. for a professional production of peptides, also supply polypeptide raw materials, Hangzhou Go Top peptide Biotech Co., Ltd. is small famous in the field of domestic polypeptide company, the size of the company, although not very large, cattle not a lot, a lot of difficult peptides, difficult modification can do.What's more, QC is rigorous and the price is reasonable.Companies or scientific institutes requiring the purchase of polypeptide raw materials are welcome to purchase them.