Hydroxypropyl-Beta-Cyclodextrin Can Increase The Solubility Of Glizide.

  Gliclazide is the second generation of oral sulfonylurea, fall blood sugar medicine can treat diabetes metabolic disorder, and can prevent vascular lesions, improve retinopathy and kidney function, is suitable for non insulin dependent diabetes, fueling and senile diabetes mellitus and cardiovascular complications of diabetes, has gradually become a line of drug use.

However, because of the low solubility and slow dissolution rate of glizide, the difference in bioavailability was significant, which affected the clinical application effect of glizide.

  Hydroxypropyl cyclodextrin (hydroxypropyl - beta-cyclodextrin) is a kind of fine pharmaceutical auxiliary material with broad development prospect.

It not only has high water solubility and the renal non-toxic, and mucous membrane is almost no stimulation to muscle, was that of HPBCD difficult soluble drugs can increase the solubility and dissolution rate of drugs, improve drug bioavailability and stability.

Binzhou zhiyuan biological production of hydroxypropyl betatophenol was carried out by the us food and drug administration DMF for the record number: 030168.