February 16, 2022
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According to statistics from the World Health Organization (WHO), nearly 2 billion people are overweight or obese worldwide. Every year, overweight or obesity causes 2.8 million deaths.
What’s Orlistat?
Orlistat is a lipase inhibitor used in the treatment of obesity that works by inhibiting fat-metabolizing enzymes. It was approved by the FDA for use in combination with a reduced-calorie diet in 1999. This drug is a generally well-tolerated and effective weight-loss aid.
What’s the mechanism of action?
Orlistat is a drug designed to treat obesity. It’s a potent and selective inhibitor of various lipase enzymes responsible for the metabolism of fat. It acts in the gastrointestinal (GI) tract via covalent binding to the serine residues located on the active site of both gastric and pancreatic lipase. When orlistat is taken with food containing fat, it partially inhibits the hydrolysis of triglycerides. This decreases absorption of monoaclglycerides and free fatty acids, contributing to weight maintenance and weight loss.
We supply 3-Hexyltetrahydro-4-hydroxy-6-undecyl-2H-pyran-2-one (CAS NO.104801-96-9) with high quality. It is used in preparation of Orlistat impurity F for quality control of Orlistat and its active pharmaceutical ingredient. This product is an intermediate of Orlistat and ready for mass production.
About us
Huateng Pharma, a global supplier of pharmaceutical intermediates, PEG derivatives, excipients, APIs and other chemical products. At present, Huateng Pharma has established a 5000 square meters R&D center, equipped with nearly 100 sets of high-end analytical and testing instruments and automatic reaction equipment.
We also have a 34,000 square meter manufacturing site with advanced design concept of intelligent manufacturing, which can realize the integration of the production process and accomplish the complete transformation of lab scale - pilot plant - large-scale commercial production, with an annual capacity of more than 1 billion RMB. We supply CAS NO.104801-96-9 with capacities varying from gram to kilograms to multi tons with high purity to our customers all over the world. Contast us at sales@huatengusa.com for more details.
Hunan Huateng Pharmaceutical Co. Ltd.
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