Heart: Natriuretic Peptide Levels Are Important Prognostic Significance In Failed Atrial Fibrillatio

Natriuretic peptides are important prognostic markers in patients with heart failure (HF), however, their prognostic significance in patients with atrial fibrillation (AF) without HF is poorly understood, and natriuretic peptide levels in these patients are underutilized in daily clinical practice.

Recently, Heart, an authoritative journal in the field of cardiology, published a research article, a prospective community-based survey of patients with atrial fibrillation in Fushimi-ku, Kyoto, Japan.Researchers investigated patients with atrial fibrillation without HF (defined as a prior HF hospitalization, New York Heart Function Class (>2), or left ventricular ejection fraction <40%) using data on B-type natriuretic peptide (BNP, n=388) or N-terminal of B-type natriuretic peptide precursor (NT-proBNP, n=771).Researchers used conversion formulas to convert BNP to NT-proBNP and grouped patients according to quartiles of NT-proBNP levels, and compared background and outcomes.

1159 patients (mean age 72.1 + 10.2 years, median CHA2DS2-VASc score 3, oral anticoagulant (OAC) prescription 671 (56%), median NT-proBNP 488 (IQR 169-1015) ng/L), older patients with higher NT-proBNP levels, higher CHA2DS2-VASc score, and more OAC prescriptions (all P < 0.001).Kaplan-Meier curves showed that NT-proBNP levels were significantly associated with higher rates of stroke/systemic embolism, all-cause death, and hospitalization for heart failure during a median follow-up period of 5.0 years (log-rank test, all P < 0.001).Multivariate Cox regression analysis showed that NT-proBNP levels remained an independent predictor of adverse outcomes even after adjustment for various confounders.

Therefore, NT-proBNP level is an important prognostic marker of poor prognosis in patients without HF AF, and may have important clinical value.

For any requests of Peptide for research purpose, welcome to contact us. www.gtpeptide.com , sales1@gotopbio.com.