Great Progress Has Been Made In The Research Of Antimicrobial Peptides

In recent years, due to the extensive use or abuse of broad-spectrum antibiotics and antibacterial drugs, a variety of drug-resistant bacteria or fungi have emerged in large numbers. Every year, nearly one million people worldwide die from bacterial infections that cannot be treated with ordinary antibiotics.At the same time, due to insufficient research and development capabilities of new antibacterial drugs,  the drug-resistant genes of various bacteria themselves can be transmitted horizontally, which greatly reduces the therapeutic effect of existing antibiotics,and humans may face the arrival of the post-antibiotic era when no effective antibiotics are available.

Antimicrobial peptides are a kind of small peptide molecules with antibacterial activity. They have attracted worldwide attention because of their rapid sterilization and difficulty in causing microbial resistance. They can be used in the research and development of new antimicrobial drug candidate molecules. The team led by Lai Yi, a researcher at the Kunming Institute of Zoology, the Chinese Academy of Sciences, identified more than 1,000 antibacterial peptides, and based on this, structurally and functionally modified the antibacterial peptides to improve antibacterial activity, reduce toxicity, and reduce costs.

ZY4 is an antibacterial peptide recently designed and modified by the team, which has strong antibacterial activity, high stability and low toxicity. ZY4 shows highly efficient and rapid bactericidal activity against drug-resistant Acinetobacter baumannii and Pseudomonas aeruginosa. At the same time, ZY4 also has significant elimination effects on the biofilm and Persister cells of these two bacteria. Z animal experiments show that ZY4 can significantly inhibit the spread of Acinetobacter baumannii and Pseudomonas aeruginosa in the body and lung infection and inflammation caused by Pseudomonas aeruginosa. This research provides a good candidate drug molecule to cope with the increasingly serious problem of transmission and infection of drug-resistant Acinetobacter baumannii and Pseudomonas aeruginosa.

GT peptide is expert at high quality custom peptide synthesis for most biotech companies and academic institutes and consistently meet the highest standard of quality, custom service and technical support. On aspect of antimicrobial peptides, our company also develop and supply these antimicrobial peptides  like LL-37,HUMAN  and LL-37, reverse sequence. Hepcidin-1(mouse), Hepcidin-20(human),  SMAP 29 (Sheep Myeloid Antimicrobial Peptide 29), mCRAMP(mouse),etc. 

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