Glezt-hydroxypropyl-cyclodextrin inclusion complex

Greazide (gliclazide,GZ) (1- (3-nitrogen heterocyclic [3.3.0] Helsinki) -3-teresulfonylurea) is the second generation oral sulfonylurea hypoglycemic agent; mainly used in the treatment of non-insulin-dependent diabetes (NIDDM). Due to strong hydrophobicity, small water soluble, slow dissolution rate and irregular bioavailability, which affects the clinical application of G Z.At the same time, GZ, as an oral hypoglycemic agent, also has the side effects leading to hypoglycemia.

Glezite-hydroxypropyl-cyclodextrin were prepared by hydroxypropyl-cyclodextrin (HP-β-CD) and hydroxypropyl methylcellulose (HPMC) in order to increase Glezide solubility, improve bioavailability, reduce the number of administration, prolong the duration of action, and reduce the fluctuation of blood drug concentration.GZ coated with hydroxypropyl cyclodextrin can increase solubility and bioavailability; using slow-release preparations can reduce the number of doses and prolong the action time, reduce the fluctuation of blood concentration and reduce toxic side effects, enhance patient compliance and obtain better treatment effect.