Functional modified cyclodextrin is widely used in medicine

Due to the low water solubility and slow metabolism of natural CD, it is not suitable for use, and it is usually stored in the form of insoluble cholesterol complex and produces toxicity in the organs.In actual drug design and production, the structure of CD is modified to improve its physical, chemical and biological properties.Such as to improve certain properties of CD, methyl, ethyl, hydroxypropyl, glucose and other groups to introduce CD molecules, destroy the CD intramolecular hydrogen bonding, through to the structure of free hydroxyl alkyl, hydroxyalkyl or esterification, synthesis of water-soluble good, amorphous, high physical stability and biological toxicity low CD derivatives, improve the application performance and application scope.At present, there are more than 10 kinds of foreign preparations listed with modified CD as auxiliary material, and the quantity is increasing.In the aspect of injection, a variety of injection and infusion agents have been approved for clinical application due to the excellent performance of modified hp-ace-cd and sbe-ace-cd.The new dosage form can reduce the toxic and side effects of the drug to some extent, and improve the solubility, dissolution rate and bioavailability of the drug.At present, CD and various derivatives have been used in more than 30 pharmaceutical products worldwide.Several oral solutions and injection products have been marketed in the United States.Hydroxypropyl - beta - CD, for example, is applied to Sporanox/(including drug Itraconazole Itraconazole, oral solution and intravenous injection), while beta CD sulfonated butyl used in hydrochloric acid Ziprasidone capsule Geodon  (including drug Ziprasidone mesylate, muscle injection), voriconazole Vfend (including drug Voricanazole,Pulse injection) and made pp azole Abilify  (including medicine, made pp azole Aripiprazole, intravenous injection).