Enrofloxacin hydroxypropyl cyclodextrin inclusion

Enrofloxacin is also known as ethyl ciprofloxacin and enrofloxacin. It is a yellowish or yellowish crystalline powder with bitter taste, insoluble in water, broad spectrum antibacterial activity and strong permeability. It has strong killing effect on Gram-negative bacteria and good antibacterial effect on Gram-positive bacteria. Its metabolite is ciprofloxacin and still has powerful antibacterial effect.

Using hydroxypropyl cyclodextrin with high solubility, enrofloxacin, which is almost insoluble in water, is encapsulated to form a stable inclusion complex. The solubility of enrofloxacin hydroxypropyl cyclodextrin in water phase is obviously improved, and the dissolution rate is high. And the yield is also greatly improved.The dissolution rate and release rate of enrofloxacin hydroxypropyl cyclodextrin inclusion compound were increased, and the absorption of drugs by organisms was increased, which was beneficial to the bioavailability of drugs.After inclusion of enrofloxacin by hydroxypropyl cyclodextrin, enrofloxacin enters the hole, which can prevent drug volatilization, sublimation, oxidation and light decomposition.It can also significantly reduce the toxicity and irritation of drugs.