Embedding method of dexamethasone with hydroxypropyl beta cyclodextrin

Dexamethasone is a kind of adrenocorticosteroids mainly used to treat collagen diseases, such as rheumatoid arthritis, dermatomyositis and so on. Because of poor solubility, the bioavailability is relatively low, and its clinical application is limited.

Dexamethasone is a white or almost white crystalline powder; odorless, slightly soluble in acetone, methanol, ethanol or dioxane, slightly soluble in chloroform, slightly soluble in ether, and almost insoluble in water.

Dexamethasone was embedded in a saturated aqueous solution using hydroxypropyl betacyclodextrin, which was completely soluble with water at 1:1, and the color of the solution remained unchanged.

Of course, it can also be buried in the simplest way. When it comes to precipitation, it can be filtered.

After burying, drying can be done.

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