Effective Use Of Levosimendan Inclusion With Betadex Sulfobutyl Ether Sodium

Levosimendan is an optical isomer of Simeontan, and it is a new type of positive inotropic drug. It mainly increases the myocardial contractile protein's sensitivity to Ca2 + and opens the K + channel sensitive to adenosine triphosphate (ATP) enzyme on the cell membrane, thereby increasing the myocardial contractility while expanding the peripheral blood vessels and coronary arteries, reducing the load on the heart. In addition, levosimendan also has pharmacological effects such as anti-inflammatory, anti-oxidation, anti-apoptosis, and anti-cardiac stun. The drug can effectively enhance myocardial contractility but does not increase myocardial oxygen consumption and has no significant effect on heart rate. While effectively alleviating symptoms, it can improve prognosis and reduce mortality.

Levosimendan is marketed as an ethanol solution and should be stored at low temperatures. The invention consists of using water as a solvent to make injections or drops, oral solutions and sprays, avoiding the use of organic solvent ethanol, and its preparation is safer, more stable and less irritating.

Inclusion of Levosimendan using betadex sulfobutyl ether sodium to make Levosimendan soluble. The prepared injection is safe, stable, effective and easy to operate.