Dosage of desiccant for effervescent tube cap

Effervescent tablet is a special dosage form containing effervescent disintegrant. This drug has high requirements on the moisture resistance of the effervescent tube, and a desiccant is placed inside to absorb moisture. The dosage of desiccant is related to the stability of the drug, how to determine its dosage?

caps for effervescent tube

144mm*29mm eff tablet tube supplier

desiccant cap

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The desiccant inside the effervescent tube is mainly silica gel, molecular sieve or an equal proportion mixture of the two. The amount of desiccant is a very critical point in the application of desiccant. If the amount of desiccant is too small, it will not have an effective moisture-proof effect, and the product will be easily damaged by moisture; if the amount of desiccant is too much, it will cause waste, Uneconomical.

Water vapor transmission rate (g/m2·day) refers to the gram weight of water vapor permeating the test material after a test time of 24 hours in a static environment under a stable temperature and humidity condition. Before starting to calculate the amount of desiccant, we must set a target humidity, which is the higher humidity allowed in the package. Generally speaking, ordinary products can be safely stored in a humidity environment below 50%, and there are many products that require lower humidity, such as 20% environment. The lower the target humidity setting, the more desiccant is required to keep the package dry. Combined with the water vapor transmission rate of the barrier packaging, the amount of desiccant can be calculated through a special formula.

The amount of desiccant in the effervescent tube is an important factor affecting the overall moisture resistance of the package. When choosing a package, pharmaceutical companies should not only consider its quality, but also the amount of desiccant to avoid moisture deterioration of the drug.