Detailed interpretation of HSPC for medicinal injection grade hydrogenated soybean lecithin

Hydrogenated Soybean Phosphatidylcholine, also known as HSPC, will be familiar to you. The HSPC supplied by AVT is a medical injection-grade hydrogenated soybean lecithin. As a semisynthetic phospholipid, the content of 1, 2-distearyl lecithin is no less than 98%, which is suitable for the preparation of liposomes. Next, Xiaobian will introduce the characteristics, parameters and application of HSPC to you in the form of video

I. Basic information of hydrogenated soybean phospholipids
Hydrogenated Soy Phospholipids, Soy Hydrogenated Lecithin, Hydrogenated Lecithin (Soy)
| English name: Hydrogenated soy phosphatidylcholine
| chemical name: HSPC
| CAS: 92128-87-5
Login | EINECS no. : 295-786-7
| levels: medicinal injection level
| and registration number: F20170000148
| DMF registration number: 027072
| properties: this product is white powder, odourless. Soluble in n-hexane, hot Yi alcohol, insoluble in water.
| content: 90.0% or higher (see the COA for the indicators)
| molecular weight (about) : 762.09
| phase transition temperature of 50 ℃
Application of hydrogenated soybean phospholipids in liposomes

As a semisynthetic phospholipid, HSPC with a certain purity can be used in some special preparations, such as liposomes, instead of total synthetic phospholipids. Doxil and Ambisome are all based on HSPC membrane materials.

1, Ambisome B liposome injection (Ambisome, 1990)

Indications: Severe deep Jun sensation RAN.
HSPC Usage: Dissolve in appropriate organic solvent together with phospholipids and drugs, spin steam in 55℃ water bath, vacuum to make film.

2, doxorubicin liposome injection (Doxil, 1995)

Indications: Advanced ovarian AI, multiple bone marrow AI and HIV complicated with Kaposi meat LIU.
HSPC usage: Soluble with phospholipids in appropriate organic solvents, under the condition of 55℃ water bath and rapid stirring, inject water solution containing doxorubicin at a slow and uniform rate to form uniform colostrum.

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