Cyclodextrin and antitumor natural products

There are a wide variety of natural products with antitumor activity, including terpenoids, lactone, saponins, alkaloid polysaccharides, flavonoids and quinones. These natural products mainly show the anti-tumor activity of inhibiting tumor cell proliferation, promoting tumor cell apoptosis, inducing tumor cell differentiation, reversing multidrug resistance of tumor cells, and the stability of telomerase. Most of them are difficult to dissolve and are easy to oxidize and are sensitive to light and thermosensitive, which restricts its clinical application.

The above defects can be solved by forming inclusion complexes with cyclodextrins. It is found that cyclodextrin and its derivatives can be well formed with its inclusion complex, and the physicochemical properties of cyclodextrin are improved, especially the solubility and stability of the cyclodextrin. Cyclodextrins can form inclusion complexes with many kinds of antitumor natural products. After the inclusion of cyclodextrin, the antitumor natural products improved their physicochemical properties, solubility and stability, and their biological activities were not affected. Through the preparation of anti-tumor natural products / cyclodextrin supramolecular system, an anti-tumor natural product drug preparation with high water solubility, high activity and low toxicity was prepared.

Shandong Binzhou Zhiyuan Biotechnology Co., Ltd. is a manufacturer specializing in the production of cyclodextrin and its cyclodextrin derivatives, with the largest quantity and the most complete specifications, and can also customize all kinds of cyclodextrin products for you.