Customization of inclusion complex of soybean isoflavone beta-cyclodextrin

The estrogenic effect of soybean isoflavones affects hormone secretion, metabolic biological activity, protein synthesis and growth factor activity. It is a natural cancer chemical preventive agent. Delaying female aging, improving menopausal symptoms, osteoporosis, elevated blood lipid, breast cancer, prostate cancer, heart disease, osteoporosis, cardiovascular disease, etc. Soybean isoflavones can improve the symptoms of myocardial ischemia, dilate blood vessels, inhibit platelet aggregation, reduce blood cholesterol and triglyceride content, and have anti-arrhythmic effect.
Cyclodextrin is widely used as a drug carrier, which can improve the water solubility and stability of drugs. Hydroxypropyl-beta-cyclodextrin (HP-beta-CD) is one of the most widely used cyclodextrin derivatives. The synthetic experiments showed that the water solubility and stability of soybean isoflavones were significantly improved after inclusion with cyclodextrin.