ChemExpress ADC One-Stop Service Platform

ChemExpress leads the field for ADC drug development providing one-stop CRO & CDMO services for both ADC small molecule and ADC conjugation. Our facilities include R&D laboratories, kilogram-scale GMP plants and commercial-scale GMP manufacturing plants. We also have more than 230 experienced R&D scientists who specialized in the area of the ADC small molecules. This enables us to provide end-to-end project support from discovery to commercialization.

ADC Payload-Linker Service Platform

ChemExpress ADC CDMO Services

We have assisted with the launch of the ADC drug RC48, the first ADC drug developed and approved in China. We have a substantial inventory of over 80 payloads and 400 linkers, in addition to extensive experience in linker compound synthesis with over 1,000 successful syntheses. This equips us to deliver ADC small molecules in quantities ranging from milligrams to kilograms. To date, we've empowered over 780 clients to develop their ADC projects. We center our efforts on putting customers first and driving innovation. With our clients, we are committed to making drug R&D more efficient, faster to market, and earlier benefiting human health.

• Payloads (80+): MMAE, Exatecan, Eribulin, PBD dimers, PNU-159682, Amanitin, Tublysin, Doxorubicin, etc.
• Linker (400+): Fmoc-Val-Cit PAB, NHS-PEG2-SS-PEG2-NHS, N-Boc-diethanolamine, etc.

Learn more>>

ChemExpress ADC Small Molecules

ADC Conjugation Service Platform

ChemExpress conjugation R&D team has accumulated in-depth experience in various bioconjugation technologies. The conjugation techniques include non-site-specific conjugation based on lysine and cysteine, as well as site-specific conjugation techniques such as ThioMAb, disulfide bridging, enzymatic catalysis conjugation, and non-natural amino acids, meeting ADC R&D needs.

Learn more>>

ChemExpress ADC Conjugation Platform

ADC Analytical Service Platform

We have a comprehensive analytical platform for bioconjugates, equipped with state-of-the-art analytical equipment to thoroughly characterize bioconjugates, including DAR (Drug-to-Antibody Ratio), impurity, endotoxin levels, concentration, free-drug content, and more.

Learn more>>

ChemExpress ADC Analytical Platform

ADC Manufacturing Facility

ChemExpress has 1 ADC R&D site located in Shanghai, and 2 manufacturing sites located in Anhui and Chongqing, respectively. All sites meet GLP/GMP requirements.

In Shanghai, the high potency R&D facility is designed to ADC R&D, route confirmation, process optimization and GLP toxicological batch production:

• Equipment: Isolator (OEB5); 50L reactor; 100L extraction vessel; 20L rotary evaporator
• Daily capacity up to 1000L of processed solution

ChemExpress High Potency R&D Facility

In Anhui, the Ma'anshan HPAPI manufacturing facility is designed to product OEB5 (OEL 0.01μg/m3) compounds:

• Highly potent kilo GMP manufacturing plant：~47,000ft²
• HPAPI plant total reactor capacity: 4,000L
• Compliant with FDA/EMA/NMPA regulatory standard
• 4 production lines equipped with negative pressure isolators which meet OEL regulations (OEB5, OEL 0.01μg/m3)
• Passed 2 EU QP audits

ChemExpress Ma'anshan Manufacturing Facility

In Chongqing, the future GMP ADC manufacturing facility is designed for the conjugation of antibody drugs.

• Total Area：~400,000ft²
• Production lines：

a) Protein Related Drug DS: multiple production scales at 200L, 500L, 2000L

b) 1 DP filling line

c) 2 Lyophilization production line

d) 1 Conjugation production line 200L

ChemExpress Chongqing Manufacturing Facility

ChemExpress is actively expanding the XDC service platform

Building on years of accumulation and in-depth work in the ADC field, ChemExpress has developed a diverse conjugation technology platform to support XDC projects. This platform includes a variety of advanced conjugation technologies. By integrating different technological approaches, we can offer our clients more flexible and customizable solutions, providing strong support for the R&D of clients' XDC pipelines. Additionally, our supporting GMP facility is under rapid construction to meet the growing demands.

Learn more>>

ChemExpress XDC platform

Helpful Resources

ChemExpress ADC Small Molecule Product Handbook>>

ChemExpress ADC CDMO Services Brochure>>