Boyee wet nano-grinding technology: effectively improve medicine dissolution rate and solubility

According to statistics, about 45% of active pharmaceutical ingredients face medicine development challenges due to their low dissolution rate and solubility in water.

These problems not only affect the bioavailability of medicines, but also limit the full play of medicine efficacy. The emergence of wet nano-grinding technology provides new hope for these poorly soluble medicines.

When the particle size of medicine particles is reduced to 100-200 nm, their dissolution rate and solubility are improved.

01

The principles and advantages of medicine nanomaterials

medicine nanocrystals refer to the refinement of medicine particles to the nanoscale, thereby increasing their specific surface area and further enhancing dissolution rate and solubility.

Pictured: Boyee 0.3L nanopharmaceutical experimental machine, self-circulating grinding system, supports CIP/SIP

This technology is based on the nanoscale effect. By reducing the particle size, medicine molecules can more easily come into contact with water molecules, thereby accelerating the dissolution rate and improving bioavailability.

medicine nano-sizing has become an important direction to improve medicine performance and promote the development of new medicines.

02

How wet nano-grinding technology works

Wet nano-grinding technology is a top-down preparation process. In the bead mill, a certain proportion of grinding media needs to be pre-filled. These media generate huge energy under high-speed rotation and effectively break up the raw material particles.

Figure: Schematic diagram of the working principle of wet nano-grinding machine of Boyee Experimental Machine

Through the collision and extrusion of the grinding media and the rotor in the liquid, the medicine particles are gradually refined to the nanometer level.

The size and material of the grinding media as well as the grinding parameters (such as rotation speed, time, and temperature) all have an important influence on the particle size distribution of the final material.

03

Effect of grinding parameters on particle size distribution

Grinding speed: Although increasing the speed can accelerate the reduction of particle size, its influence on the final material particle size is not decisive.

There is a delicate balance between rotation speed and grinding time, indicating that within a certain range, the optimization of grinding time is more critical.

Picture: Boyee Reactor

Grinding time: As the grinding time increases, the medicine particles become finer, but over-grinding may lead to particle agglomeration or crystal transformation, so precise control is required.

Use of dispersant: As a key factor in controlling the particle size of nanoparticles, the addition of dispersant can effectively reduce the interaction force between particles, prevent agglomeration, and ensure the stable dispersion of nanoparticles.

Pictured: Boyee batching tank

In the field of medicine research and development and production, the dissolution rate and solubility of medicines are key indicators for measuring medicine quality.

Wet nano-grinding technology provides a new solution to the problem of medicine formulation for poorly soluble medicines.

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