September 13, 2020
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AVT brings you high-purity injectable-grade sucrose products, and as a pharmaceutical excipient, AVT's sucrose products need to highlight the following features GMP grade and low endotoxin, so what kind of sucrose product is this? And what are the physicochemical properties? Follow along to find out!
English name: sucrose
Product name: Sucrose (for injection)
Chemical name: α-D-Glucopyranoside, β-D-fructofuranosyl-sucrose
CAS No. 57-50-1
UNII No. C151H8M554
Structural formula:
Molecular formula: C12H22O11
Molecular Weight: 342.33
Physical and chemical properties.
Sucrose is sweet, odorless, easily soluble in water and glycerin, slightly soluble in alcohols. Relative density 1.587 (25°C). It has polarizing properties, but no variable polarizing effect. Sucrose is extremely soluble in water, and its solubility increases with the increase of temperature, and does not conduct electricity after dissolving in water. Sucrose is also soluble in aniline, azobenzene, ethyl acetate, amyl acetate, molten phenol, liquid ammonia, mixture of alcohol and water, and acetone and water. Water mixtures, but not soluble in gasoline, petroleum, anhydrous alcohol, chloroform, carbon tetrachloride, carbon disulfide and turpentine. Organic solvent. Sucrose is a crystalline substance. The specific gravity of pure sucrose crystals is 1.5879 and the specific gravity of sucrose solutions varies according to concentration and temperature. The specific spin of sucrose ranges from +66.3° to +67.0°.
Sucrose and sucrose solutions are subjected to various chemical reactions by heat, acid, alkali, and yeast. Crystallized sucrose melts into a thick, transparent liquid when it is heated to 160°C and then crystallizes again when it is cooled. When heated for a longer time, sucrose decomposes into glucose and defructose. At higher temperatures of 190-220°C, the sucrose is dehydrated and condensed into caramel. When the caramel is further heated, products such as carbon dioxide, carbon monoxide, acetic acid and acetone are formed. Under humid conditions, sucrose decomposes at 100°C, releasing water and turning black. When the sucrose solution is heated for a long time under atmospheric pressure, the dissolved sucrose will slowly decompose into equal amounts of glucose and fructose, which means the conversion will take place. Effect. If the sucrose solution is heated to above 108°C, the hydrolysis is rapid, and the greater the concentration of the sugar solution, the more significant the hydrolysis. The metal material used to boil the vessel also has an effect on the sucrose conversion rate. For example, the sucrose solution has a much greater conversion effect in copper than in silver, and glass containers have little effect.
The sucrose products offered by AVT are high purity, low endotoxin injectable grade pharmaceutical sucrose, which is often used in pharmacy as a lyophilization protectant in the following applications Nano preparations and protein biologics, etc. It acts as a low-temperature protectant in the freeze-drying process and as a dehydration protectant in the drying and dehydration process, and it can also adjust the osmotic pressure. It is recognized as one of the most widely used and most effective freeze-drying protectants.
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