Application of sulfobutyl betacyclodextrin sodium in injection

Sulfobutyl betacyclodextrin sodium can not only increase the solubility of the drug, improve the stability and safety of the drug, but also reduce the irritation of the injection on the administration site, so that the drug can quickly reach the required blood concentration and extend the action time of the drug.Currently, Pfizer has successfully developed the injection of ziprasidone, an antipsychotic drug with SBECD as the inclusion material, and it has been listed in the United States and Sweden.SBECD has the advantages of high safety, strong solubilization and inclusion ability, and has a broad application prospect as an auxiliary material for injection.Examples are as follows:Fentanyl (fentanyl) is a kind of synthetic opioid receptor agonist, which belongs to strong analgesics and is used for sedation and analgesia before, during and after anesthesia.It is commonly used for injection because of the large effect of oral administration.Fentanyl et al. studied the potential of SBECD as an excipient to improve the efficacy of fentanyl for injection.It was found that fentanyl formed a 1:1 inclusion compound, and the drug was used as a drug reservoir to release the drug slowly, so as to achieve long-term effects.Using SBECD as solvent and stabilizer, it is possible to prepare fentanyl for long - term injection.Amphotericin B is a broad-spectrum antibacterial agent of polyene, used for systemic fungal infection.The inclusion compound injection prepared by amphotericin b-sbecd can increase the stability of amphotericin B and improve the drug safety, so as to improve the therapeutic window of amphotericin B in clinical practice.Amiodarone is Ⅲ anti-arrhythmic drugs, is widely used in the treatment of arrhythmia.With SBECD as the solvent, a safer and more effective amiodarone injection can be prepared, reducing the risk of hypotension after administration.Shandong zhiyuan biological new modern GMP workshop, the production of injection grade sulfobutyl betacyclodextrin sodium stable quality, high quality, is your ideal choice.