Application of modified cyclodextrin in medicine

In view of its low water solubility, slow metabolism, which is not conducive to use, and often accumulated in the form of insoluble cholesterol complex in organs and other limitations. In the actual drug design and production, the structure of CD has been modified to improve its physicochemical and biological properties. For example, some properties of CD are improved by introducing methyl, ethyl, hydroxypropyl, glucosyl and other groups into CD molecule to destroy the hydrogen bond in CD molecule. Through alkylation, hydroxyl alkylation or esterification of free hydroxyl groups in the structure, good water solubility and no toxicity can be obtained CD derivatives with high physical stability and low physiological toxicity improve their application performance and application range.