Application of inclusion complexes of cyclodextrins and derivatives in preparations

The inclusion technology has been widely used in the pharmaceutical field. As the main molecule of the inclusion compound, the cyclodextrin and its derivatives have been deeply studied in the preparation products in recent years. The host molecule has a large hole structure, which is enough to accommodate the guest molecules to form a sac. As the drug is wrapped, the solubility of the drug is increased, the stability is increased, the liquid medicine can be powdered. It can prevent volatile components from volatilization, mask the bad odor of drugs, regulate the rate of drug release, improve the bioavailability of the drug, and make a powder injection agent.

For example, ranitidine hydrochloride has a bad odor and is made into its cyclodextrin inclusion complex, which improves the odor and improves the compliance of patients. Norfloxacin is insoluble in water and low in oral utilization. The relative bioavailability of hydroxypropyl cyclodextrin inclusion compound is increased to 141.6%. At present, the product varieties produced by the inclusion technology have been widely listed, including the canonical buccal tablets, Piroxicam Tablets and Spironolactone Tablets, so as to make the preparation of the products have a good effect.

Shandong Binzhou Zhiyuan Biotechnology Co.,Ltd is the largest manufacturer of engaged in cyclodextrin Pharmaceutical Excipients ,Cyclodextrin Reagents,Cyclodextrin Complex in China.