Application of hydroxypropyl betadex and curcumin inclusion complexes

Hydroxypropyl betadex (HP-βCD) is a cyclodextrin derivative often used to improve the solubility and stability of drugs. curcumin (also known as curcumin) is a compound with antioxidant and properties commonly found in turmeric. The purpose of forming the inclusion compound of curcumin and hydroxypropyl betadex is mainly to have the following applications:

Increased solubility of curcumin: The bioavailability of curcumin is limited by its low water solubility. The inclusion compound of curcumin with hydroxypropyl betadex can increase the solubility of curcumin in water and thus improve its oral bioavailability.

Enhance the stability of curcumin: curcumin is easily degraded by factors such as light, heat and oxygen in the environment. By forming clathrates, the stability of curcumin can be improved, its degradation process can be slowed down, and its retention time in the preparation can be prolonged.

Improved curcumin bioavailability: The formation of clathrates may help increase the absorption and distribution of curcumin in the body, thereby increasing its bioavailability. This is very important to improve the efficacy of curcumin.

Regulating the release rate of curcumin: Clathrates can affect the release rate of curcumin in the body, thereby regulating the duration of its effects. This could be beneficial for controlling the drug's behavior in the body and improving efficacy.

In general, through the formation of inclusion compound with hydroxypropyl betadex and curcumin, the physicochemical properties of curcumin can be improved, its stability and bioavailability in preparations can be improved, and its pharmacological effects can be better played. This approach is often used in drug development and formulation optimization.