Application of Hyaluronic Acid in ophthalmology

What is hyaluronic acid? Hyaluronic Acid, HA for short, commonly known as Hyaluronic Acid. Because in 1934, the British in 1934, the professor of ophthalmology at Columbia University in the United States Meyer and so on were the first to isolate the vitreous body from the bovine eye.

Hyaluronic acid (HA) is distributed in various parts of the human body, and is one of the main matrix components of the skin epidermis, as well as one of the main components of cell matrix, so it has good safety and biocompatibility when used as excipients. In addition to its application in orthopedics and tissue engineering, it has also been used in ophthalmic nursing and zhi therapy, such as lens implantation, corneal transplantation and other ophthalmic operations and the production of eye drops.

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Application in ophthalmic surgery

High molecular hyaluronic acid is usually used as viscoelastic agent in ophthalmic surgery. With its good viscoelasticity and poor fluidity, it can be used as a gel to support the anterior chamber, providing a clear vision for the operation and reducing the damage to the cornea. At the same time, hyaluronic acid gel can compress the bleeding site, exert the molecular blocking effect to inhibit the movement, proliferation, differentiation and phagocytosis of ZHI cells, and reduce the occurrence of postoperative inflammation.

Application of eye drops

Currently, hyaluronic acid is a better and safer medium in ophthalmic preparations. It can not only play its own hydrating and moisturizing effect in the eyes, relieve dry eyes, but also increase the bioavailability of drugs, reduce the irritation of drugs on the eyes, promote the healing of eye wounds, and quickly relieve the symptoms of discomfort.

Drug sustained-release effect: the hydrophilic group in HA molecule interacts with mucin, which can delay the elimination of drugs and improve bioavailability. Physical viscosification can increase the drug retention time in vivo to improve the efficacy. Spreading and wetting ability: HA can effectively prolong tear film rupture time, lubricate and protect eyeball, relieve dryness of eye and protect cornea. HA is a safe and effective drug for dry eye treatment. It is also a safe and effective viscosifier in many eye drops.

Chobe launched its HA product, cosmetic grade HA, in 1984 and has continued to export new products to the market ever since. In addition to basic hyaluronic acids (cosmetic, food and pharmaceutical), it also has three proprietary products developed by itself -- functional hyalo-Oligo ®, Hyaloveil®-P and Hyalorepair®.

Osmotic Hyalo-Oligo® -- moisturizes the skin from the inside out

It is a low molecular weight hyaluronic acid with an average molecular weight of less than 10,000. The nanometer level enables it to cover the surface of the skin, but also to penetrate deep into the stratum corneum, from the inside of the skin to play a hydrating role. The common hyaluronic acid stays on the skin surface and is therefore easily lost after washing; In contrast, Hyalo-Oligo® retains the moisturizing properties of hyaluronic acid after cleansing. International Patent: WO2007/099830 A1.

Adsorbed Hyaloveil®-P -- a thin film reservoir for continuous moisture retention

Is a cationic hyaluronic acid, with a positive charge, can be adsorbed on the surface of the skin and hair with a negative charge to form a layer of hyaluronic acid film, so that it will not be easily washed away by water, better achieve the "after cleaning can continue to moisturize" this characteristic. This trait can also help us resist drastic environmental changes and keep our skin healthy and hydrated. International public patent: WO2008/133267 A1.

Repair HyalorePair ® -- Enhances the skin barrier ability

It is part of the hydrophilic sodium hyaluronate that is attached to hydrophobic groups, giving the "hydrating" HA new abilities that "can act on the skin barrier". HyalorePair ® restores and enhances the barrier function of the skin by repairing the skin's dry lamellar structure disorder. International public patent: WO2011/102462 A1.

With the development of medical science and technology, the application of hyaluronic acid in medical Yao will be more and more widely. As a giant in R&D and production of hyaluronic acid, Japan's century-old enterprise Chubby Co., Ltd. is a global supplier of raw materials with a wide variety of products and excellent quality. As DU's agent in China, our company sells all kinds of hyaluronic acid products produced by Chobe, and the medical grade has been registered in CFDA, which can be used by major domestic scientific research institutes and pharmaceutical enterprises. The price is favorable. Welcome to call our 400 number