Application of Betadex sulfobutyl ether sodium

Name: Betadex sulfobutyl ether sodium 

Other name： Sulfobutyl ether-beta-cyclodextrin sodium salt

Sulfobutyl ether-β-cyclodextrin sodium salt;

Sulfobutyl Ether-Beta-cyclodextrin

CAS#: 182410-00-0

DMF NO.: 030167

Abbreviation: SBEBCD/SBE-β-CD

Molecular formula : C42H70-nO35 (C4H8O3S Na)n

Molecular weight: 1135+158n

Qaulity： injection grade

Standard： USP/EP

Package：10kg (10kg/1bag), 10kg( 2kg/bag, 5bag/1drum), 20kg (20kg/1bag)

Use：Medical field

Features and applications:

Betadex sulfobutyl ether sodium is the product that β-Cyclodextrin 6 (also including 2, 3) OH is substituted by Sulfobutyl. It can be divided into single substitution, multiple substitution and total 6 substitution β-Cyclodextrin. The molecular formula is therefore different. Betadex sulfobutyl ether sodium has special affinity and inclusion for drugs containing nitrogen. Betadex sulfobutyl ether sodium is an important modified production of Beta-Cyclodextrin. Which has its own characteristics in addition to the ones Beta-Cyclodextrin has.

Betadex sulfobutyl ether sodium(SBE-β-CD) is a high water-soluble anionic cyclodextrin derivative. It can easily form non-covalent inclusion complexes with drug molecules.

Betadex sulfobutyl ether sodium(SBE-β-CD)has been used in injection, oral, nasal and eye medication. Modification by charged functional units can improve the binding affinity of cyclodextrins for oppositely charged guests, so it has a special affinity for drugs with nitrogen elements.

Betadex sulfobutyl ether sodium mainly used in anti-cancer drugs, sucha as : Voriconazole/Posaconazole/Delafloxacin.

Main Application:

1. Improve the stability, water solubility and safety of drugs.
2. Reduce renal toxicity and drug hemolysis
3. Control the drug release rate, cover the bad smell
4. Increase bioavailability
5. It is mainly used in the azotic medicine as an excipient.