Application of Amyloid Peptides

Amyloid, first discovered to be associated with diseases like Alzheimer's disease, has recently been recognized as a biological structure that plays an important physiological role in host organisms.A recent review by Soultan Al-Halifa and his colleagues in PeptideScience specifically addressed the potential applications of amyloid in Nanovaccine engineering and biosensing.

Amyloid is a highly organized protein structure with unique mechanical, physical and biological properties.Halifa and his colleagues detailed these properties, including self-assembly of polypeptide chains, high mechanical resistance, ability to regulate the structure and morphology of amyloid, biocompatibility and biodegradability, high thermal stability, chemical and enzymatic stability.

The material has good biocompatibility, biodegradability and stable amyloid structure, and is suitable for nanovaccine.Without the drawbacks of traditional vaccines, nanomycin can trigger immune responses, such as inactivation of viruses to return virulence, weak immune responses, or allergy to vaccine vectors.The self-assembled structure of amyloid protein was used as an experimental platform for Nanovaccine to make amyloid resistant to protein hydrolysis.This amyloid structure can also carry multiple copies of antigenic determinants, resulting in a stronger immune response.

At the same time, the biocompatibility and biodegradation of amyloid are also utilized by nanotechnology.In addition, modification of the monomer peptide sequence in the amyloid structure improves the physical, chemical and mechanical control of the final amyloid structure.Ideally, amyloid assemblies (functionalized by appropriate molecules) can be used to study nanoscale biological events.

In addition to the Human Disease Amyloidosis Association, Al-Halifa and his colleagues are also studying how to better utilize these folded protein structures to make them more dynamic.Although challenges remain, the authors remain optimistic that the wide application of amyloid structure, including growth of amyloid, is still not accurately controlled.Scientists have noticed that there will be many scientific problems in utilizing the structure of amyloid, which will be solved in many fields, including nanowires and biosensing.

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