Allicin hydroxypropyl-β-cyclodextrin package intestinal soluble capsule

Allicin is a broad-spectrum antimicrobial drug, which has a long history of adding medicine in China. It is the main bioactive ingredient in garlic. It has the effects of lowering blood pressure, lowering blood lipid, reducing coronary arteriosclerosis, preventing cancer, cancer treatment, antiviral, inhibiting platelet accumulation and other effects.Allicin is the main effective component of garlic volatile oil, it has a strong antibacterial, inhibit tumor cell growth and prevention and control of atherosclerosis and other effects, so that allicin has a good development prospect.Allicin is volatile, bad smell and insoluble in water, greatly limited its scope and extent of clinical application.At present, although there are allicin tablets and capsules in clinical application, but the preparation of materials, to a large extent affected the allicin effect, such as previously reported-cyclodextrin material allicin, prepared into capsule or tablets, and the preparation run to the intestinal tract, intestinal body fluid is not very sufficient, cyclodextrin itself solubility in water is very small, so limited the dissolution of coated allicin and absorption.

HPBCD is used as the inclusion material to solve the volatility of allicin, and does not affect the dissolution and absorption of the package allicin. It makes the package into an intestinal soluble capsule, and overcomes the smell and gastric irritation of allicin, which has the prospect for development and research.