A nasal spray was prepared by dimethyl-β-cyclodextrin

Caffentanyl (CFTN) is a derivative of fentanyl with significant analgesic effects but poor water soluble. The dimethyl-β-cyclic dextrin (DM-β-CD) package and its nasal spray carrying CFTN were prepared by ultrasonic method to increase the solubility of CFTN. The dissolution of the clite is significantly higher in hydrochloric acid and free CFTN. buffer In vivo trials were performed using the rat model, with intravenous, intramuscular, oral and nasal drops to CFTN-DM-β-CD clusions (250 μg/kg). Results As compared to intramuscular injection and oral administration, CFTN-DM - β-CD envelopes are absorbed faster via nasal administration, and have more cmax and bioavailability. Therefore, the CFTN-DM-β-CD envelope nasal spray is a relatively safe, fast-acting, and effective dosage form.

Shandong Binzhou Zhiyuan Biotechnology Co., Ltd. is a high-tech enterprise focusing on the research, development, production and application of circumdextrin derivatives, cyclodextrin packaging compounds and new circumdextrin materials. Founded in 2010, the company covers an area of 30,000 ㎡, construction area of 10,000 ㎡, fixed assets of 150 million yuan, including inspection instruments worth more than 20 million yuan, with a complete research and development, quality inspection center and professional scientific research team, maintains long-term cooperative relations with Nankai University, Shandong University, has many provincial, municipal and other research and development platforms.