|
Arshine Group Co.,Ltd.
|
At room temperature, it is a white crystalline powder with hygroscopicity and is highly soluble in water. When dissolved, it releases heat.
Fosfomcyin sodium can bind to a bacterial cell wall synthase, hindering the first step reaction of bacteria in synthesizing cell walls using relevant substances, thereby exerting a bactericidal effect. It has antibacterial effects on Staphylococcus, Streptococcus pneumoniae, Escherichia coli, Neisseria gonorrhoeae, Proteus mirabilis, Salmonella typhi, most Pseudomonas aeruginosa, Streptococcus pyogenes, Streptococcus faecalis, some indole positive Proteus, and some Klebsiella and Enterobacteriaceae bacteria. Fosfomycin sodium is mainly used in clinical practice to treat infections caused by sensitive Gram negative bacteria in the urinary tract, urinary system, skin and soft tissue, respiratory tract, intestinal tract, and other areas. It can also be used in combination with other antibiotics to treat severe infections caused by sensitive bacteria, such as sepsis, lung and meningeal infections, peritonitis, adnexitis, intrauterine infections, pelvic inflammatory disease, osteomyelitis, etc. It can also be used in combination with vancomycin to treat methicillin-resistant Staphylococcus aureus infection.
pharmacological action
1. It has a wide antibacterial spectrum, high bioavailability, fast absorption, strong antibacterial ability, and is not affected by diet. It has bactericidal activity against both Gram positive and negative bacteria, especially against Pseudomonas aeruginosa, Proteus, Salmonella, as well as Staphylococcus aureus and Escherichia coli that are resistant to various drugs. Used in animals, there is no resistance or cross resistance, and the clinical treatment effect is good.
2. Rapid sterilization: This product is a rapid bactericidal agent, and its effect is obvious after 1-2 hours. About 25% of Escherichia coli are exposed to phosphomycin (12.5) μ Killed within 1 hour and all within 4-6 hours. Pseudomonas aeruginosa and Staphylococcus aureus were also completely killed at 4 and 8 hours, respectively.
3. Low toxic side effects, minimal stimulation to the body, no acute toxicity or adverse reactions, and will not increase the burden on the kidneys. 4. Low residue: The elimination time for achieving residue standards in muscles and organs is 48-72 hours.
Fosfomcyin calcium Usage: Mainly used to treat infections caused by Escherichia coli, infectious serositis, Salmonella, Klebsiella pneumoniae in poultry and livestock, as well as infections caused by Pasteurella, Vibrio, Staphylococcus aureus, Streptococcus, and other Gram negative bacteria in fish and shrimp |
Send Inquiry
|
Pharma Sources Insight June 2024: Globalization on the Go
