Cas no for 20830-81-3,Daunomycin ACID Cas number search msds database,online free cas number chemistry search engine,cas number sigma aldrich

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Home > CAS No. Inquiry > 20830-81-3

20830-81-3

[CAS Name] Daunomycin

[Formula] C27H30ClNO10

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Basica Info

[CAS Name]Daunomycin
[Alias](8s-cis)-8-acetyl-10-((3-amino-2,3,6-trideoxy-alpha-l-lyxo-hexopyranosyl)oxy)-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-5,12-naphthacenedione hydrochloride; DAUNORUBICIN; DAUNORUBICINE HYDROCHLORIDE; DAUNOMYCIN HYDROCHLORIDE; LEUKAEMOMYCIN C HYDROCHLORIDE; (8s-cis)-8-acetyl-10-[(3-amino-2,3,6-trideoxy-alpha-l-lyxo-hexopyrannosyl)oxy]; 3-acetyl-1,2,3,4,6,11-hexahydro-3,5,12-trihydroxy-10-methoxy-6,11-dioxo-1-naph; 3-acetyl-3,5,12-trihydroxy-10-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-1-yl 3-amino-2,3,6-trideoxyhexopyranoside; (1S,3S)-3-acetyl-3,5,12-trihydroxy-10-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-1-yl 3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranoside; (1S,3S)-3-acetyl-3,5,12-trihydroxy-10-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-1-yl 3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranoside hydrochloride (1:1); (7S,9S)-9-acetyl-6,9,11-trihydroxy-4-methoxy-7-tetrahydropyran-2-yloxy-8,10-dihydro-7H-tetracene-5,12-dione; ammonia; methane; molecular hydrogen; hydrate; hydrochloride
[Number]20830-81-3
[EINECS]244-069-7
[Formula]C27H30ClNO10
[Molecular weight]565.99668

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Beijing Global Biologicals Co.Ltd

Anti-cancer Product Daunorubicin

Specification:

Similar to Doxorubicin, Daunorubicin interacts with DNA by intercalation and inhibition of macromolecularbiosynthesis. This inhibits the progression of the enzyme topoisomerase II, which relaxes supercoils in DNA for transcription. Daunorubicin stabilizes the topoisomerase II complex after it has broken the DNA chain for replication, preventing the DNA double helix from being resealed and thereby stopping the process of replication. On binding to DNA, daunomycin intercalates, with its daunosamine residue directed toward the minor groove. It has the highest preference for two adjacent G/C base pairs flanked on the 5' side by an A/T base pair. Daunomycin effectively binds to every 3 base pairs and induces a local unwinding angle of 11°, but negligible distortion of helical conformation.^[5] It can also induce histone eviction from chromatin upon intercalation.

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Beijing Global Biologicals Co.Ltd

It is a chemotherapeutic agent belonging to the anthracycline antibiotics and is used to treat certain types of cancer,mainly for leukemia treatment. It can slow or stop the growth of cancer cells and is usually used in combination with other chemotherapeutic drugs. Approach of administration depends on the type of tumor.

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Chemtour Biotech（Suzhou）CO.,Ltd

MF: C27H29NO10

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