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Shandong Binzhou Zhiyuan Biotechnology Co., Ltd.
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The research on the biological stability of drugs is mainly limited to the anti-enzymatic hydrolysis ability of biological agents such as proteins, peptides and enzymes. For example, l-asparaginase is one of the earliest protein macromolecular biochemical drugs, which is mainly used in acute lymphoblastic leukemia.However, as a kind of enzyme protein preparation, the stability of the drug affects and limits its clinical application to a certain extent.The thermal stability and antitrypsin hydrolysis ability of l-asparaginase -cd inclusion compound were studied after lyophilization. The results showed that -cd can significantly increase the stability of drug and is a good enzyme protectant.Cyclodextrin protein drugs protection reasons might be: protein molecular surface distribution of polar amino acid residues, the polarity of these residues side chain with beta CD molecules form hydrogen bond of hydroxy, thus embedded in the beta CD's mouth water, or residue side chain insert beta CD internal tubular structure, side chain alkyl chain in the hydrophobic bonding and beta CD molecular interactions, the hydrophobic portion of space hole side chain at the same time outside the polar groups and beta CD molecules at the mouth of the close water to form hydrogen bond, forming a stable clathrate.In addition, cyclodextrin can also solve the biological products in water easy to form a dimer, polymer, or easy to be the container wall non-specific adsorption caused by the biological sample activity reduction and other problems.
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Shandong Binzhou Zhiyuan Biotechnology Co., Ltd.
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Sertraline is selective serotonin recycle inhibitor (SSRI), the latest in a can help to improve the ability of the body, effectively alleviate the patient's depressive symptoms, including irritable mood, and can reduce the fatigue and anxiety state of sustainability, has a long-term, low poisonous to the cells of liver, the body clear, very suitable for the elderly taking etc., in the world has been widely used to treat depressive and obsessive-compulsive disorder.Compared with sertraline hydrochloride tablets, the oral liquid containing sertraline hydrochloride has the advantages of convenient taking, stable storage at low or normal temperature, fast absorption, good taste, more suitable for elderly patients, simple process and material saving.The present invention solves the sertraline hydrochloride oral liquid preparation technology on the key problem of solubility and stability problems, choose in the use of doses non-toxic excitant hydroxypropyl times he almost cyclodextrins and sugar mixture of lauric acid ester as solubilizer and stabilizer, which provides a with hydroxypropyl times he cyclodextrins and sugar mixture of lauric acid ester as solubilizer and stabilizer of sertraline hydrochloride oral solution. Shandong binzhou wisdom source biological technology co., LTD., is committed to specializing in the production of pharmaceutical excipients hydroxypropyl times he cyclodextrins and sodium sulfonated butyl times he cyclodextrin, has standard GMP management, advanced production equipment, professional team of experts, the sale of our products at the same time, also widely used in food, cosmetics, scientific research and other fields, you just need to, we just professional, welcome from all walks of life to come to visit.
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Shandong Binzhou Zhiyuan Biotechnology Co., Ltd.
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Name: Hydroxypropyl Betadex
Other Name : 2-hydroxypropyl-beta-cyclodextirn ;
Hydroxypropyl-β-cyclodextrin.
Abbreviation : HPBCD
CAS: 128446-35-5
EINECS: 420-920-1
Molecular formula : C42H70-nO35(C3H8O2)n
Molecular weight: 1134.98+58n
Solubility (in 100cm3 solvent, at 25℃) : Water: >180g
Methanol: >33g
DMSO: >33g
Qaulity ：Pharma grade
Standard : USP42/ EP9.6
Package: 500g/bag , 2kg/bag, 10kg/drum
Use : Medical field
Applications In pharmaceuticals industry:
Hydroxypropyl Betadex can increase solubility and bioavailability of insoluble drugs, so that the efficacy of drugs can last longer with less ingestion of drugs. It can adjust and control drugs release ratio, decrease side effects of drugs, and enhance stability of drugs. HP-β-CD can be used for oral medication, injection, mucosal delivery systems (including the nasal mucosa, rectum, cornea, etc.), dermal drug delivery systems, lipophilic drugs targeting delivery, and also used as protective agent and stabilizer of protein.
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Pharma Sources Insight June 2024: Globalization on the Go
