Cas no for 204255-11-8,Oseltamivir phosphate ACID Cas number search msds database,online free cas number chemistry search engine,cas number sigma aldrich

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Home > CAS No. Inquiry > 204255-11-8

204255-11-8

[CAS Name] Oseltamivir phosphate

[Formula] C16H28N2O4·H3PO4

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Basica Info

[CAS Name]Oseltamivir phosphate
[Alias](3R,4R,5S)-4-Acetamido-5-amino-3-(1-ethylpropoxy)-1-cyclohexene-1-carboxylic acid ethyl ester phosphate (1:1)
[Number]204255-11-8
[EINECS]
[Formula]C16H28N2O4·H3PO4
[Molecular weight]410.4

204255-11-8 Suppliers

Company

Main Products

Sinoway Industrial Co.Ltd.

Product Information

Product name	Oseltamivir Phosphate
Molecular Formula	C16H28N2O4.H3PO4
Molecular Weight	410.4
CAS No.	204255-11-8
Quality Standard	99% up, medical grade
Appearance	White powder

COA of Oseltamivir Phosphate

Test Item	Specification	Results
Appearance	White to off-white crystalline powder	White crystalline powder
Specific rotation	-30.7o ~ -32.6 o	-31.4 o
Identification:	IR: Spectrum of the sample corresponds to that of reference standard.	Conform
Identification:	HPLC: The retention time of major peak of test solution should correspond to that of comparison solution.	Conform
Related substances	Impurity I NMT 0.1%	0.01%
	Impurity II NMT 0.1%	ND
	Impurity III NMT 0.1%	0.04%
	Impurity IV NMT 0.1%	0.01%
	Each of unspecified impurity NMT 0.1%	0.05%
	Total impurities NMT 0.5%	0.1%
Related solvents	Acetone NMT 5000ppm	81ppm
	Ethanol NMT 5000ppm	ND
	Dichloromethane NMT 600ppm	ND
	Ethyl acetate NMT 5000ppm	ND
	n-Heptane NMT 5000ppm	ND
	Toluene NMT 890ppm	ND
Water	NMT 0.5%	0.3%
Heavy metals	NMT 10ppm	Conform
Assay	98.0% ~ 101.5% (on anhydrous basis)	99.4%
Conclusion	The product conforms to the above specifications

Usage

Funtion of Oseltamivide phosphate
Oseltamivide phosphate is rapidly metabolized to oseltamivir carboxylate by absorption through the gastrointestinal tract and at least 75% of the oral dose is involved in systemic circulation in the form of oseltamivir carboxylate.

The active ingredient Is a potent and unique neuraminidase inhibitor that acts on all aspects of influenza virus infection andprevents the replication of all clinically relevant strains of influenza A or B viruses. In vitro in very low nanomolar concentrations that have inhibitory effect.
The active metabolite was observed to inhibit the growth of influenza virus in vitro and it was also observed in vivo to inhibit the replication and pathogenicity of influenza virus.

Oseltamivide phosphate reduces the spread of influenza A or B viruses by inhibiting the release of the virus from the infected cells.

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Senova Technology Company Limited

Oseltamivir Phosphate is an orally active inhibitor of influenza virus neuraminidase

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Shenzhen Sijia Pharmaceutical Co., Ltd.

Above products are not available in patent covered areas, or only used for laboratory research and development.

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Product Information

Product name

Oseltamivir Phosphate

Molecular Formula

C16H28N2O4.H3PO4

Molecular Weight

410.4

CAS No.

204255-11-8

Quality Standard

99% up, medical grade

Appearance

White powder

COA of Oseltamivir Phosphate

Test Item

Specification

Results

Appearance

White to off-white crystalline powder

White crystalline powder

Specific rotation

-30.7o ~ -32.6 o

-31.4 o

Identification:

IR: Spectrum of the sample corresponds to that of reference standard.

Conform

HPLC: The retention time of major peak of test solution should correspond to that of comparison solution.

Conform

Related substances

Impurity I NMT 0.1%

0.01%

Impurity II NMT 0.1%

ND

Impurity III NMT 0.1%

0.04%

Impurity IV NMT 0.1%

0.01%

Each of unspecified impurity NMT 0.1%

0.05%

Total impurities NMT 0.5%

0.1%

Related solvents

Acetone NMT 5000ppm

81ppm

Ethanol NMT 5000ppm

ND

Dichloromethane NMT 600ppm

ND

Ethyl acetate NMT 5000ppm

ND

n-Heptane NMT 5000ppm

ND

Toluene NMT 890ppm

ND

Water

NMT 0.5%

0.3%

Heavy metals

NMT 10ppm

Conform

Assay

98.0% ~ 101.5% (on anhydrous basis)

99.4%

Conclusion

The product conforms to the above specifications

Usage