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Shandong Loncom Pharmaceutical Co.,Ltd.
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Product Description
Product name Lacosamide
Synonyms (R)-2-Acetamido-N-benzyl-3-methoxypropanamide
CAS 175481-36-4
Molecular Formula C13H18N2O3
Molecular Weight 250.29
Product Feature
Apperance White or off white crystalline powder
Identification IR; HPLC
Melting point 140－145℃
Specific rotation +14º－+17º
Water (KF) NMT 0.5%
Residue on ignition NMT 0.3%
Heavy metals NMT 30PPM
Max single impurity: NMT 0.5%
Total impurity: NMT 1.0%
S -isomer NMT 1.0%
Assay (HPLC ) 98.0－102.0%
Lacosamide is a functionalized amino acid compound specifically synthesized as an anticonvulsive drug to use as add-on therapy for partial-onset seizures with antinociceptive and neuroprotective activities. Lacosamide selectively enhances slow inactivation of voltage-gated sodium channels without affecting fast inactivation, thereby stabilizing hyperexcitabe neuronal membranes. Furthermore, this agent binds to collapsin response mediator protein 2 (CRMP2; DPYSL2), a cytosolic phosphoprotein expressed in most tissues. In the nervous system, CRMP2 acts as a mediator of growth cone collapse as well as modifies axon number, length, and neuronal polarity. |
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Shandong Chuancheng Pharmaceutical Co.,Ltd.
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Shandong Chuancheng Pharmaceutical Co., Ltd., located in the "Jiangbei Water City" reputation of the chat city. The company covers an area of 53,300 m2, with a total investment of 397 million yuan. To produce API and pharmaceutical intermediates mainly, built with apitic drug workshop four, purification workshop, power workshop, environmental protection workshop, etc. , is a set of pharmaceutical research and development, production, sales and technical services in one of the high standards of pharmaceutical enterprises.
The company has a complete GMP system, equipped with four major laboratories for synthesis, analysis, environmental protection, and microbiology. Equipped with an audit tracking system of ICP-MS, liquid, gas and other types of imported chromatographic instruments nearly 20, equipped with complete physical and chemical instruments.
In terms of honors, the company is a high-tech enterprise, Shandong province "Specialized special new" enterprise, city-level Key Laboratory Laboratory, innovative small and medium-sized enterprises, new research and Development Institutions, Liaocheng Enterprise Technology Center.
Shandong Chuancheng Pharmaceutical Co. , Ltd. is willing to cooperate with old and new friends who share the common value! |
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Pharma Sources Insight June 2024: Globalization on the Go
