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Sinoway Industrial Co.Ltd.
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Product name
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Candesartan cilexetil
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CAS No.
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145040-37-5
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Molecular Formula
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C33H34N6O6
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Molecular Weight
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610.66
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Quality Standard
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99% up, Medicine Grade
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Appearance
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White powder
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COA of Candesartan cilexetil
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Items
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Specifications
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Results
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Appearance
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A white or almost white powder
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White powder
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Identification-IR
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Complies with the reference spectrum
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Complies
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Identification- UV
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Maximal absorptions at 254nm,
minimum absorption at 242nm
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Complies
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Water
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≤ 0.3%
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0.19%
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Residual solvents
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Methanol
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≤ 3000ppm
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Not found
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Ethanol
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≤ 5000ppm
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Not found
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Ethyl ether
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≤ 5000ppm
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68ppm
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Acetone
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≤ 5000ppm
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482ppm
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Ethyl acetate
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≤ 5000ppm
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Not found
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Dichloromethane
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≤ 600ppm
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Not found
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Dimethylformamide
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≤ 880ppm
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Not found
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Related substances
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Impurity A
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≤ 0.15%
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< 0.05%
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Impurity B
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≤ 0.3%
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< 0.05%
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Impurity F
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≤ 0.2%
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< 0.05%
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Impurity G
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≤ 0.2%
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< 0.05%
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Impurity H
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≤ 0.15%
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Not found
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Other individual impurity
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≤ 0.10%
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0.04%
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Total impurities
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≤ 0.6%
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0.21%
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Sulfated ash
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≤ 0.1%
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0.06%
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Heavy metals
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≤ 10ppm
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<10ppm
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Assay (Dried substance)
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99.0~101.0%
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99.8%
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Conclusion:
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The product complies with EP 9.0
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Function of Candesartan cilexetil
Candesartan cilexetil is an angiotensin II receptor antagonist, also referred to as an ARB drug for short. Candesartan cilexetil is currently recognized as a first-line treatment for hypertension. Candesartan cilexetil tablets can bind to the AT1 receptor of vascular smooth muscle, thereby antagonizing the vasoconstriction effect of angiotensin II and reducing the resistance of peripheral blood vessels.
Among the similar ARB drugs, candesartan cilexetil has the strongest receptor affinity, so it has a longer binding time, so it is a long-acting angiotensin II receptor antagonist, which can be administered once every 24 hours. Can play a stable, long-lasting and effective antihypertensive effect. Not only that, studies have found that candesartan cilexetil can also improve fibrinolytic activity, promote the recovery of vascular endothelial function, and help protect cardiovascular and cerebrovascular other than blood pressure. |
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