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Rensin Chemicals Limited
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Florfenicol is a thiamphenicol derivative with the same mechanism of action as chloramphenicol (inhibition of protein synthesis). However, it is more active than either chloramphenicol or thiamphenicol, and may be more bactericidal than previously thought against some pathogens (e.g., BRD pathogens). Florfenicol has a broad spectrum of antibacterial activity that includes all organisms sensitive to chloramphenicol, gram-negative bacilli, gram-positive cocci, and other atypical bacteria such as mycoplasma. Florfenicol is highly lipophilic, which provides high enough concentrations to treat intracellular pathogens and cross some anatomic barriers (penetration across the blood–brain barrier in cattle is 46%). The half-life of florfenicol is 2-3 hours in cattle after IV administration, but it is prolonged (18 hours) after IM injection, and 27 hours after 40 mg/kg subcutaneously. In dogs, the half-life is shorter, with values of 1.1 and 1.2 after IV and oral administration, respectively. The half-life in cats is approximately 4 hours and 7.8 hours after IV and oral administration, respectively. |
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HEBEI HUANWEI BIOTECH CO.,LTD.
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Fluphenicol shows white or white-like crystalline powder, odorless, and bitter taste. It is easily dissolved in dimethyl for mamide and methanol, slightly dissolved in water, glacial acetic acid or chloroform. Florfenicol is a special antibiotic for animals.It is currently a commonly used veterinary antibiotic with a broad antibacterial spectrum and a strong antibacterial effect as well as a low the minimum inhibitory concentration (MIC). The antibacterial of florfenicol is about 15-20 times as high as that of chloramphenicol and the thiamphenicol. After administration through feed for 60 minutes, the drug concentration in the tissue can reach peak which can quickly control the disease with having characteristics such as being safe, non-toxic, no residue, and no risk for triggering aplastic anemia.
Therefore, it is quite suitable for large-scale farms application. It is mainly used for the treatment of bovine respiratory disease caused by Pasteurella and Haemophilus. It has good efficacy in treating the cattle footrot disease cause by Fusobacterium, and can be also used for treating the infection diseases of pigs and chickens caused by sensitive strains as well as the bacterial disease of fish. |
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CHANGSHA CHEMOWAY IMP&EXP CO., LTD
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Changsha Chemoway Co., Ltd. was founded in historical famous city Changsha .Since our foundation, we have been devoted to the trade of basic chemical materials, pharmaceutical intermediates, pigment and dye intermediates, food and industrial additives and special chemicals. Up to now, we have become a global supplier for chemical products with world-wide sales network and steady supply channels.
Due to years′ experiences and professional background in chemical industry, we have successfully established closely and steadily cooperative relationships with many famous international and domestic chemical companies such as BASF, Lanxess, Lawter, NALCO and Thermo Fisher, etc.
We commit to international market and supplier management. We complement each other′s advantages with large manufacturers in Shandong, Jiangsu, Zhejiang and other provinces. Through establishing strategic partnership with some manufacturing enterprises, we have owned synergistic effect now with them. Now, we are offering powerful supports to these manufacturing enterprises for helping expanding businesses into international market!View more |
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Pharma Sources Insight June 2024: Globalization on the Go
