Pduct Name: Silymarin (Milk Thistle P.E.)
Latin Name: Silybum marianum (Linn.) Gaertn
Used Part: Seed
Specification Available: 80% Silymarin
Active ingredient: Silymarin,Silybin
CAS No.: 65666-07-1
Best Raw Material without pollution:
Function: Silymarin refers to the extract from the seeds of the plant Silybum marianum, also called “milk thistle.” It has been used for over 2,000 years. During the Middle Ages, the seed of the milk thistle was commonly used to treat liver diseases.The active ingredients of milk thistle are chemicals called flavonoids. The flavonoids in milk thistle are silybin, silydianin, and silychristin. Together, they are called silymarin.
Specification(80% Silymarin):
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Appearance:
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Yellow powder with slight characteristic smell
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Solubility:
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Soluble in acetone and methanol, insoluble in water
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Heavy metals:
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10 ppm Max.
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Sulphated ash:
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0.6% Max.
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Loss on drying (2 hours 130°C):
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5.0% Max.
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Mesh size:
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5% through 80mesh
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Extract Solvent:
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Acetone
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Silybin assay: (on dry basis)
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80% Min. by UV
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Silymarincontent/HPLC:USP29
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(1)SilybinA.B.
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(2)IsosilybinA.B.
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(3)Silydianin&Silychristin
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Residual Organic Solvents:
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(1) Total
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0.5% Max.
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(2) Acetone
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0.45% Max.
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(3)Others
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0.05% Max.
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Microbiological test:
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Total Plate Count
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1,000cfu/g Max.
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Moulds & Yeasts
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100cfu/g Max.
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E.Coli
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Negative
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Salmonella
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Negative
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Milk Thistle P.E. ( Silymarin 40%)
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Appearance:
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Light Yellow Fine Powder
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Identification:
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Positive Reaction
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Heavy metals:
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10 ppm Max.
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Sulphated Ash:
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1.0% Max.
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Loss on drying:
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4.0% Max.
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Assay: ( Silymarin) by
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UV: 40% Min.
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Residue solvents:
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Negative
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Microbiological Test:
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Total plate count:
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1000/g Max
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Yeast and mould:
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100/g Max.
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Escherichia Coli:
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Negative
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Salmonella:
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Negative
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Pharma Sources Insight January 2025
